Exam topic

Airway and RSI Questions on the Paramedic Exam: What to Know

Airway and RSI questions on the paramedic exam reward one habit above all others: oxygenation comes first, and every device, drug and attempt is judged by whether it keeps the patient oxygenated. Most items ask you to predict a difficult airway, choose the safest next step, pick a drug that fits the patient, prove where the tube is, or move on when an attempt fails.

This post walks through the five areas in the order you meet them on a call: assessment, preoxygenation, RSI drug choices and doses, confirmation with waveform capnography, and the failed-airway plan. Two sample questions show how the exam turns those rules into decisions.

What airway and RSI questions on the paramedic exam test

The National Model EMS Clinical Guidelines describe airway care as an escalation: open and clear the airway, add an oral or nasal airway, ventilate with a bag-valve mask, consider noninvasive ventilation, then a supraglottic airway, then intubation, and a surgical airway only when oxygenation cannot be maintained any other way. Exam items are built on that ladder. The right answer is usually the least invasive step that will work now, not the most advanced skill on the list.

  • Recognize the patient who needs ventilation, not just oxygen: falling mental status, slow or shallow breathing, rising end-tidal CO2.
  • Bag well: two-person, two-thumbs-up seal, just enough volume for chest rise, 10 to 12 breaths a minute for an adult, with PEEP starting around 5 cm H2O.
  • Know when an advanced airway is indicated and when it is not, including the guideline point that pediatric intubation has unclear benefit in the field.
  • Keep peri-intubation hypoxia (SpO2 under 90%) and hypotension from happening, since the guidelines track both as quality measures.

Practice free in your browser

Airway assessment: predicting a difficult airway

Before any drug is drawn up, the exam expects you to ask two questions: will laryngoscopy be hard, and will bag-mask ventilation be hard? Two mnemonics answer them, and items often test whether you match the right one to the right task.

The 3-3-2 rule: three fingers of mouth opening, three from chin to hyoid, two from hyoid to thyroid notch.
MnemonicPredictsWhat it covers
LEMONDifficult laryngoscopyLook externally, Evaluate 3-3-2, Mallampati, Obstruction, Neck mobility
MOANSDifficult bag-mask ventilationMask seal, Obesity or obstruction, Age over 55, No teeth, Snoring or sleep apnea

The NASEMSO guideline lists the same warning signs in plain terms: a short jaw or limited jaw thrust, small thyromental space, large tongue, obesity, large neck, facial hair, prior neck surgery, trismus, and traumatic injuries to the face, neck or chest. A scenario that mentions any of these is telling you to plan for failure before the first attempt, with a bougie, a supraglottic airway and a surgical kit ready.

Preoxygenation and apneic oxygenation

Preoxygenation fills the lungs with oxygen so the patient tolerates the apnea of RSI. The traditional end points are 3 minutes of tidal breathing on high-concentration oxygen or eight vital-capacity breaths through a tight-fitting mask. Noninvasive ventilation can improve oxygenation before intubation in some patients with respiratory failure, and a nasal cannula left on high flow during the attempt (apneic oxygenation) may lengthen the time before desaturation.

  • Elevate the head when possible; positioning improves both mechanics and the view.
  • Suction a soiled airway before the attempt; the guideline links this to first-pass success.
  • Routine cricoid pressure is not recommended in adults or children.
  • Resuscitate before you intubate: positive pressure after intubation lowers preload, so fix hypotension and hypoxemia first.

RSI drug choices and doses

The exam asks less about memorizing every dose and more about matching the drug to the patient. The table gives label ranges for adults; your agency protocol sets the doses you actually use, and many emergency RSI protocols use the higher end of the paralytic ranges.

Ranges from the DailyMed prescribing information for each drug. Follow your protocol.
DrugLabel adult IV doseOnsetWhat exams test
Etomidate0.2 to 0.6 mg/kg (usual 0.3)Within 1 minLittle effect on BP; cortisol suppressed 6 to 8 h; myoclonus
Ketamine1 to 4.5 mg/kg, given slowlyWithin 30 sRaises HR and BP; avoid when a BP rise is a hazard
SuccinylcholineAverage 0.6 mg/kg (0.3 to 1.1)About 1 minShort: recovery in 4 to 6 min; hyperkalemia risks
Rocuronium0.6 to 1.2 mg/kg for RSIUnder 2 minLong: median 67 min at 1.2 mg/kg; sedate after the tube

Induction agent: etomidate or ketamine?

Ketamine is the classic exam answer for the patient in severe bronchospasm, and its label notes that it often raises heart rate and blood pressure. In the large RSI trial of 2,365 critically ill adults, ketamine and etomidate had similar 28-day mortality (28.1% vs 29.1%), but cardiovascular collapse during intubation was more common with ketamine (22.1% vs 17.0%). For a patient on the edge of shock, the better answer is often to resuscitate first and have a pressor ready, whatever the induction agent.

Paralytic: when succinylcholine is wrong

Succinylcholine can cause a dangerous potassium rise. Its label contraindicates it after the acute phase of major burns, multiple trauma, extensive denervation or upper motor neuron injury, and with malignant hyperthermia risk or skeletal muscle myopathy, and carries a boxed warning about hyperkalemic cardiac arrest in children with undiagnosed myopathy. When a stem mentions burns from several days ago, a stroke or spinal cord injury beyond the acute phase, neuromuscular disease or a missed dialysis run, rocuronium is the answer. Because rocuronium lasts far longer than any induction dose, post-intubation sedation and analgesia must follow promptly.

Confirming the tube with waveform capnography

The guideline calls waveform capnography the most reliable confirmation of an endotracheal tube or supraglottic airway, and says it should be attached before the first breath through the device. Breath sounds, chest rise and oxygen saturation are less reliable, colorimetric devices are less accurate than clinical assessment, and misting in the tube is not a reliable sign at all.

  • Look for sustained exhaled CO2: a waveform that rises and falls with each breath, stays steady or grows over at least seven breaths, and peaks above 7.5 mm Hg.
  • No sustained CO2 means the default is to remove the tube and reoxygenate. In every reviewed case of unrecognized esophageal intubation where the lungs were auscultated, breath sounds were reported as present.
  • Keep capnography on for the whole transport and recheck after every patient move, because tubes are displaced during transfers.
  • Note the tube depth at the teeth or gums and secure it with a commercial holder or tape.

The failed-airway plan

Exam items treat a failed attempt as a fork in the road, not a reason to try harder. The safe sequence is to stop, reoxygenate with a bag-valve mask or a supraglottic airway, change something before any further attempt (position, blade, video laryngoscope, bougie, operator), and limit the total number of attempts.

  1. Attempt fails or SpO2 falls: stop and oxygenate by mask with adjuncts.
  2. Mask ventilation is poor: place a supraglottic airway.
  3. Cannot intubate and cannot oxygenate by any route: perform a surgical airway if trained, typically a scalpel-bougie-tube cricothyrotomy.
  4. If a tube becomes dislodged in transport, a supraglottic airway is the guideline's fallback.

Difficult-airway guidelines stress that once it is clear the patient cannot be oxygenated, the surgical airway should not be delayed. Exam stems signal this with a falling saturation after failed intubation, failed bag-mask ventilation and a supraglottic airway that will not seat.

Sample questions: preoxygenation and a failed attempt

Question 1 · Airway, Respiration and Ventilation

A paramedic is preparing a rapid sequence intubation for a 90-kg patient with a head injury who is breathing spontaneously with an SpO₂ of 95%. Which step best reduces the risk of desaturation during laryngoscopy?

  1. Limit preoxygenation to 30 seconds to shorten scene time
  2. Give the paralytic first so the sedative has time to work
  3. Ventilate vigorously with a bag-valve mask once the paralytic is given
  4. Preoxygenate for 3 minutes with a nasal cannula running during the attempt
Show the answer and rationale

Answer: D

  • A. Thirty seconds does not denitrogenate the lungs.
  • B. Sedation always precedes paralysis; the reverse leaves the patient awake and paralyzed.
  • C. Positive-pressure ventilation after paralysis inflates the stomach and risks aspiration.
  • D. Correct. Full preoxygenation plus apneic oxygenation extends the safe apnea time.

Safe apnea time depends on the oxygen reserve in the lungs. Three minutes of preoxygenation with a tight-fitting non-rebreather or bag-valve mask (or eight vital-capacity breaths) washes out nitrogen, and a nasal cannula at 15 L/min left in place provides apneic oxygenation throughout laryngoscopy. Head-up positioning helps as well.

Sources: NASEMSO Model EMS Guidelines v3.0 (2022); Walls Manual of Emergency Airway, 6th ed.

Question 2 · Airway, Respiration and Ventilation

During a first intubation attempt, the paramedic has a partial view of the glottis but the tube will not pass. The SpO₂ has fallen from 97% to 88% and is still dropping. A partner says, “You’re almost there.” What is the correct NEXT step?

  1. Withdraw the blade and repeat the same technique at once
  2. Move straight to a cricothyrotomy
  3. Stop, reoxygenate by mask, then change the approach
  4. Continue while the saturation stays above 80%
Show the answer and rationale

Answer: C

  • A. Repeating an unchanged technique, with no reoxygenation between attempts, is likely to fail the same way.
  • B. A surgical airway is for a patient who cannot be oxygenated or ventilated by other means; mask ventilation has not yet failed here.
  • C. Correct. Oxygenation comes before the tube. Mask ventilation restores the saturation, and something is changed before any further attempt.
  • D. Tempting with a partial view, but the attempt has already caused hypoxia, and hypoxia around intubation is what the guideline tells clinicians to avoid.

A failed-airway plan puts oxygenation ahead of any one device. NASEMSO asks clinicians to avoid hypoxia and hypotension during intubation attempts, and the Difficult Airway Society limits the number of laryngoscopies and warns against repeating a procedure unless something can change, such as position, device or operator. If intubation fails but mask ventilation works, a supraglottic airway provides oxygenation; if the patient cannot be oxygenated or ventilated by these means, a surgical airway follows.

Sources: NASEMSO Model EMS Guidelines v3.0 (2022); Difficult Airway Society Guidelines (2015)

In the first question the patient is still breathing with a normal saturation, so there is time to prepare. Ask which option lengthens the safe apnea time. Giving the paralytic before the sedative is wrong on drug order, a 30-second preoxygenation wastes the window you have, and vigorous bagging after paralysis inflates the stomach. The option that combines full preoxygenation with oxygen flowing during the attempt is the only one that protects the saturation through laryngoscopy.

The second question tests the failed-airway reflex. The saturation has already dropped, so continuing the attempt trades oxygen for a chance at the tube, and a fixed saturation floor of 80% is not a safe target. Jumping straight to a cricothyrotomy skips the steps that may still work. Reoxygenating by mask and then changing the approach follows the escalation every airway algorithm uses.

Frequently asked questions

How many airway questions are on the NREMT paramedic exam?

The National Registry publishes ranges for broad content areas rather than a count of airway items. Airway decisions also appear inside clinical judgment, medical and trauma questions, so expect them throughout the exam.

What is the most reliable way to confirm endotracheal tube placement?

Continuous waveform capnography showing sustained exhaled CO2. Breath sounds, chest rise and misting can all be present with an esophageal tube.

When should a paramedic avoid succinylcholine?

With known or suspected high potassium, malignant hyperthermia risk, myopathy, or after the acute phase of major burns, multiple trauma, denervation or upper motor neuron injury. Rocuronium is the usual alternative.

How long should preoxygenation last before RSI?

Traditionally 3 minutes of tidal breathing on high-concentration oxygen or eight vital-capacity breaths, with noninvasive ventilation for patients who stay hypoxic and a nasal cannula left on during the attempt.

Practice free in your browser3,050+ exam-style questions with rationales. No account, no ads. Also free on the App Store and Google Play.

Download on theApp StoreGet it onGoogle Play

Sources

  1. National Association of State EMS Officials. National Model EMS Clinical Guidelines, Version 3.0 (March 2022): Airway Management. Local copy read. Link
  2. Rocuronium bromide injection, prescribing information. DailyMed; revised 6/2025. Link
  3. Anectine (succinylcholine chloride) injection, prescribing information. DailyMed; revised 11/2023. Link
  4. Ketalar (ketamine hydrochloride) injection, prescribing information. DailyMed; revised 1/2025. Link
  5. Amidate (etomidate) injection, prescribing information. DailyMed. Link
  6. Barbosa A, Mosier JM. Preoxygenation and apneic oxygenation in emergency airway management. Clin Exp Emerg Med. 2024;11(2):136-144. Link
  7. Chrimes N, Higgs A, Hagberg CA, et al. Preventing unrecognised oesophageal intubation: a consensus guideline from the Project for Universal Management of Airways and international airway societies. Anaesthesia. 2022;77(12):1395-1415. Link
  8. Liaqat T, Amjad MA, Cherian SV. Difficult Airway Management in the Intensive Care Unit: A Narrative Review of Algorithms and Strategies. J Clin Med. 2025;14(14):4930. Link
  9. Casey JD, Seitz KP, Driver BE, et al. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2026;394(16):1608-1620. Link